The study of electrochemical behavior of ciprofloxacin (CPF) is described on a Tyrosine modified carbon paste electrode (TCPE) by using cyclic voltammetry (CV) and differential pulse voltammetric techniques. CV was used to study the influence of pH on peak current and peak potential. The phosphate buffer solution (PBS) of pH 7.0 was found to be reasonable as a supporting electrolyte for assay of the drug. The solution conditions and instrumental parameters were optimized; CPF gave a sensitive oxidation peak at 0.590 V (Vs Ag/AgCl). The peak current varied linearly with increase in the concentration from 20 µM to 80 µM. After being validated, the proposed procedure was successfully applied for the determination of the drug in tablets and human urine with mean recoveries of 99.579 and 98.559%, respectively with detection limit of 4.5µM.
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